Dragonframe 4 supports up to 512 lighting channels. The DMC+, DMC-16, and DDMX-512 all support 512 channels. The DDMX-S2 only supports 99 by default. However, you can purchase a DDMX-S2 Upgrade Chip to make it support 512.
Dragonframe 3 / Dragonframe Stop Motion 2
Dragonframe 3 supports up to 99 lighting channels. This is a limitation in the software, even if you buy the DDMX-512 or other hardware that can support 512 channels.